national cancer institute

national cancer institute

Biological Insights for Developmental Therapeutics of Pediatric Brain Tumors

1d ago
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Description

Michael Prados, MD University of California San Francisco Director of the Department's Neuro-Oncology Translational Research Program, Dr. Prados has over 25 years' experience at UCSF in treating and supervising the treatment of both adults and children who have brain tumors. The National Cancer Institute's Adult Brain Tumor Consortium, which sponsors trials of treatment regimens for brain tumors, is led by Dr. Prados along with Dr. Skip Grossman at John Hopkins, and he is Project Leader of the Pacific Pediatric Neuro-Oncology Consortium site at UCSF, which is one of 8 institutions in the West Coast of the United States that participate in cooperative effort to develop effective new strategies for treating children with malignant brain tumors. Dr. Prados also assumed leadership of a new early phase consortium called the Ivy Foundation Early Phase Clinical Trials Consortium, with a primary focus on PK/PD studies of targeted agents given at the time of surgical resection. The goal of the Consortium is to reject agents that do not have adequate tissue PK characteristics and/or do not modulate the proposed target, and enhancing development of agents that do both. His research interest is in clinical research trials for primary brain tumors. He is the Program Leader of the Neurological Oncology Program of the UCSF Comprehensive Cancer Center, and heads the Translational Division within the Department with an emphasis on the Brain Tumor SPORE grant related research that will yield clinical trials over a short time frame. Dr. Prados has been a principal investigator, co-investigator, or collaborating investigator in over 50 research protocols from the National Institutes of Health (NIH), UCSF, and Industry studies over the last several years, and currently is principal investigator or co-investigator of 4 active NIH grants. He has published over 250 peer-reviewed manuscripts and is on the Editorial Board of several journals, including JCO, Neuro-Oncology and the Journal of Neuro-Oncology.