excited delirium

excited delirium

Excited Delirium **Bad Shroom Trip** Jefferson Street Incident

1mo ago
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Here it is! The famous "Jefferson Street Incident" where crazy naked guy goes nuts on shrooms. Jim and Them Commentary Funny comentary. Kapoosh! What is Excited Delirium (ED)? Excited delirium is a brain disorder. This disorder is usually drug-related (cocaine or "crack", PCP or "angel dust", methamphetamine, amphetamine), but can occur in non-drug users as well. The presentation of excited delirium occurs with a sudden onset, with symptoms of bizarre and/or aggressive behavior, shouting, paranoia, panic, violence toward others, unexpected physical strength, and hyperthermia. Hyperthermia is a harbinger of death in these cases. Neurochemical systems in the brain are abnormal in this disorder. At the molecular level, excited delirium is characterized by dysregulated dopamine transporters (hyperdopaminergic state), elevated heat shock proteins (hyperthermia), and immediate early gene activation as a marker of paranoid aggression (c-fos protein). These molecular changes serve as biomarkers of the disorder. While many factors are associated with sudden death in individuals requiring restraint for excited delirium, these individuals develop a disturbance in thought, behavior and mood, and become agitated and violent. This abnormal behavioral state is due to CNS mechanisms which are the cause of lethality. The brain controls the heart and respiration. Abnormal brain activity leads to the psychosis and sudden death. History of Excited Delirium While excited delirium is best characterized in cocaine users, medical examiners and forensic scientists have noted a similarity in psychiatric presentation between sudden unexplained deaths in custody and psychiatric states associated with or without drug abuse. This seminal work was first described by Dr. Charles Wetli and his collaborator David Fishbain in the mid 1980s, when the "crack" cocaine epidemic first hit the streets of Miami, Florida (Wetli and Fishbain, 1985). But this disorder was known more than a decade earlier. In 1849, Dr. Luther Bell first described a "disease" resembling some advanced stage of mania and fever, distinguished as an overlooked and often unrecorded malady (Bell, 1849). This "exhaustive mania" was described in 40 cases by Dr. Bell where "exhaustion due to mental excitement" caused three quarters of these patients to die.