social behavior

social behavior

PPA Rat Pair Impaired Social

3mo ago
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Description

Behavioral videos of propionic acid infusions in rats. Single intracerebroventricular (ICV) infusions (4 µL of 0.26 M solution over 4 min) of propionic acid (PPA), a metabolic end product of autism-associated enteric bacteria, produce bouts of reversible hyperactive and repetitive behavior (A) in adult rats, compared with phosphate-buffered saline (PBS) vehicle--infused control rat (B). Rat pairs infused with PPA show markedly reduced social interaction and play behavior (C) compared with pairs of rats infused with PBS vehicle (D), which show typical social behavior. Ethovision behavioral tracking of control (left) and PPA-treated (right) rat pairs (E), showing further evidence of PPA-induced hyperactive, repetitive, and antisocial behavior. PPA-treated rat displays fixation on objects (F) and a specific object preference (ie, block vs sphere). PPA-infused rats also show turning, tics, dystonia, and retropulsion and electrographic evidence of complex partial seizures and basal ganglial spiking consistent with findings in patients with autism spectrum disorders. Modified with permission from MacFabe 2012, Microbial Ecology in Health and Disease.