amino acids

amino acids

Protein Synthesis! (Mr. W's Rock Music Video)

4d ago
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Buy the single on iTunes: https://itunes.apple.com/us/album/protein-synthesis-single/id910714339 This video teaches about protein synthesis. Lyrics! Look at what’s coming out of the nucleus Destined for a ribosome, a strand of mRNA It’s got the code, the information, For the protein we’ll be making today The RNA message is organized Into codons, that’s a sequence of bases three That spell out one and only one amino acid A genetic code that works universally A codon has its match in an anti-codon Three bases on a tRNAs bottom side tRNA’s job is to bring amino acids To ribosomes so proteins can be synthesized CHORUS mRNA, tRNA and ribosomes plus amino acids make a protein making machine Read the codon, make a polypeptide That’s translation – cells synthesizing proteins The small subunit of a ribosome binds With that mRNA’s leading end And slides until it reaches start codon AUG Indicating where translation begins A ribosome has three binding sites Where tRNAs can bind The “A” site’s first, “P”s next, then “E” And the E’s got an exit sign The first tRNA in this translation process Binds the start codon in binding site “P” And that tRNA carries an amino acid That goes by the name of Methionine. And now to finish this initiation The ribosome needs to be made complete The large subunit binds the small subunit Now we’re ready for translation to proceed. CHORUS Now we’re ready for next step: elongation An amino acid carried by a new tRNA With an anticodon matching with the second codon Binds at the site called “A” Then the ribosome carries out an enzymatic action. Binding these amino acids with a peptide bond So a dipeptide hangs on the “A” site tRNA Watch translation move along! Next the ribosome shifts exactly one codon over In a move that we call “translocation” So the “A” site’s empty, and the “P” site’s loaded And the first tRNA’s in the “E” location “E” site tRNA makes its exit And the next tRNA fills the site called “A” And the ribosome catalyzes away In your cells it happens every second, every day And watch that polypeptide, see it get longer As each and every codon get translated Ribosomal robots reading RNA instructions As proteins get created! CHORUS Bridge Protein synthesis! Translation! (repeat 4X) We started with initiation, which was followed By part two of translation: elongation Now it’s time to finish synthesizing this protein, With a finale called termination. When the ribosome gets to a stop codon There’s no tRNA anti-codon that matches So “A” site’s bound by a release factor: The polypeptide detaches tRNAs at P & E sites float away Ribosome breaks apart, no longer one The polypeptide folds into functional protein Translation is done! CHORUS BRIDGE